Jun Song Biography

Dr. Song is a molecular biologist by training, with a research focus in transcriptional regulation, cancer, epigenetics, stem cells, and Next-Generation Sequencing (NGS). His early research involved the genomic identification and characterization of transcriptional factors. Over the course of his career, Dr. Song have developed a novel RNAi vector and broaden his research in cancer and HIV research using the RNAi technology. Recently years, Dr. Song has focused on Next-Generation Sequencing (NGS) and developed a targeted sequencing technology that reduces the cost significantly. 

Research Areas Of Interest  

Cancer, Epigenetics, and Next-Generation Sequencing (NGS) 

 

Education

Ph.D., Molecular Biology 

Master, Medical Genetics 

 

Publications

•     Tang X., Saito-Ohara F., Song J., Koga C., Ugai H., Murakami H., Ikeuchi T., and Yokoyama K. K. Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization. Jpn J. Human Genet. 42:337-341  (1997). 
•     Song J., Murakami H., Tsutsui H., Tang X., Matsumura M., ItakuraK., Kanazawa I, Sun K, and Yokoyama K. K. Genomic Organization and Expression of a Human Gene for Myc-associated Zinc Finger Protein (MAZ). J. Biol. Chem. 273:20603-20614 (1998) 
•     Kawasaki H., Song J., Eckner R., Ugai H., Chiu R., Taira K., Shi Y., Jones NN., and Yokoyama K. K. p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev. 12:233-241 (1998) 
•     Song J., Murakami H, Yang Z., Koga C., Adati N., Murata T., Geltinger C., Saito-Ohara F.,  Ikeuchi T.,  Matsumura M.,  Itakura K.,  Kanazawa I.,  Sun K., and Yokoyama  K. K. Human Genes for KNSL4 and MAZ Are Located Close to One Another on Chromosome 16p11.2http://www.idealibrary.com/servlet/citation/0888-7543/52/374. Genomics 52:374-377 (1998) 
•     Song J., Murakami H., Tsutsui H., Ugai H., Geltinger C., Murata T., Matsumura M., Itakura K., Kanazawa I., Sun K., and Yokoyama K. K. Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene. Eur. J. Biochem. 259:676-683 (1999) 
•     Song J., Geltinger C., Sun K., Kanazawa I., and Yokoyama K. K. Direct Lysis Method for the Rapid Preparation of Plasmid DNA. Anal. Biochem. 271:89-91 (1999) 
•     Song J., Kanazawa I, Sun K., Murata T, and Yokoyama K. K. Removal of ethidium bromide and cesium chloride from plasmid DNA by ethanol precipitation. BioTechniques 26:1056-1060 (1999) 
•     Song J., Tsutsui H., Jin C., Ugai H, and Yokoyama K. K. The multiple roles of the transcription factors MAZ and Pur-1, two proteins encoded by housekeeping genes. Current Genomics 1:175-181 (2000). 
•     Song J., Ugai H., Kanazawa I, Sun K., and Yokoyama　K. K. Independent Repression of a GC-rich Housekeeping Gene by Sp1 and MAZ Involves the Same cis-Elements. J. Biol. Chem. 276:19897-19904 (2001) 
•     Song J., Ugai H, Ogawa K., Wang Y., Sarai A., Obata Y, Kanazawa I., Sun K., Itakura K., and Yokoyama K. K. Two Consecutive Zinc Fingers in Sp1 and in MAZ Are Essential for Interactions with cis-Elements. J. Biol. Chem. 276:30429-30434 (2001) 
•     Song J., Mangold M., Suske G., Geltinger C., Kanazawa I., Sun K., and Yokoyama K. K. Characterization and promoter analysis of the mouse gene for transcription factor Sp4. Gene 264:19-27 (2001) 
•      Zhao X., Murata T., Ohno S., Day N., Song J., Nomura N., Nakahara T., and Yokoyama K. K. Protein Kinase Calpha  Plays a Critical Role in Mannosylerythritol Lipid-induced Differentiation of Melanoma B16 Cells. J. Biol. Chem. 276:39903-39910 (2001) 
•     Ugai H, Li H., Komatsu M., Tsutsui H., Song J., Shiga T., Fearon E., Murata T., and Yokoyama K. K. Interaction of Myc-Associated Zinc Finger Protein with DCC, the Product of a Tumor-Suppressor Gene, during the Neural Differentiation of P19 EC Cell. Biochem. Biophys. Res. Commun. 286:1087-1097 (2001) 
•     Jin C., Ugai H., Song J., Murata T., Nili F., Sun K., Horikoshi M., and Yokoyama K. K. Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2. FEBS Letters 489:34-41 (2001) 
•     Chiu R., Rey O., Zheng J., TwissJ. L., Song J., Pang S., and Yokoyama K. K. Effects of Altered Expression and Localization of Cyclophilin A on Differentiation of p19 Embryonic Carcinoma Cells. Cell. Mol. Neurobiol. 23:929-943 (2003) 
•     Song J., Ugai H., Nakata-Tsutsui H., Kishikawa S., Suzuki E., Murata T., and Yokoyama K. K. Transcriptional regulation by zinc-finger proteins Sp1 and MAZ involves interactions with the same cis-elements. Int J Mol Med 11:547-553 (2003). 
•     Song J., Lu Y., Yokoyama K. K., Rossi J., and Chiu R. Cyclophilin A is required for retinoic acid-induced neuronal differentiation in p19 cells. J. Biol. Chem. 279:24414-24419 (2004) 
•     Song J., Lu Y., Pang S., and Chiu R. An internal control for immunoblot analysis using the blotted membrane. Anal. Biochem. 331:201-203 (2004) 
•     Song J., Pang S., Lu Y., and Chiu R. Poly(U) and polyadenylation termination signals are interchangeable for terminating the expression of shRNA from a pol II promoter. Biochem. Biophys. Res. Commun. 323: 573-578 (2004) 
•     Song J., Pang S., Lu Y., Yokoyama K. K., Zheng J-Y., and Chiu R. Gene silencing in androgen responsive prostate cancer cells from the tissue-specific PSA promoter. Cancer Res. 64: 7661-7663 (2004) 
•     Nishinaka T., Song J., Lum K., and Chiu R. Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue. DNA Seq. 16:147-150 (2005) 
•     Zheng J, Xie Y, Campbell R, Song J, Massachi S, Razi M, Chiu R, Berenson J, Yang OO, Chen IS, & Pang S.  Involvement of claudin-7 in HIV infection of CD4(-) cells. Retrovirology. 2:79 (2005) 
•     Zheng J, Xie Y, Campbell R, Song J, Wang RQ, Chiu R, Berenson J, Razi M, Massachi S, Yang OO, Chen IS, Pang S. gp120-Independent HIV Infection of Cells Derived From the Female Reproductive Tract, Brain, and Colon. J. Acquir. Immune Defic. Syndr. 43(2):127-136 (2006). 
•     Lu Y., Song J., Cho H., Fan G., Yokoyama K., Chiu R. Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification. J. Biol. Chem. 281(51):39081-39087 (2006). 
•     Song J, Lu Y, Giang A, Pang S, Chiu R. Promoter analysis of the mouse Peg3 gene. Biochim. Biophys. Acta 1779(2):134-138 (2008). 
•     Song J., Lu Y, Giang A, Pang S, Chiu R. Multiple shRNA expressing vector enhances efficiency of gene silencing. BMB Reports. 41(5): 358-262 (2008) 
•     Calhoun CC, Lu YC, Song J, Chiu R. Knockdown endogenous CypA with siRNA in U2OS cells results in disruption of F-actin structure and alters tumor phenotype. Mol Cell Biochem. 320(1-2):35-43 (2009). 
•     Song J, Chang I, Chen Z, Kang M, Wang CY. Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One. 5(7):e11456 (2010). 
•     Day K, Song J, Devin A. Targeted Sequencing of Large Genomic Regions with CATCH-Seq. PLoS One. 9(10): e111756 (2014). 
•     Zhang Y, Song J, Day K, Devin A. dCATCH-Seq: improved sequencing of large continuous genomic targets with double-hybridization. BMC Genomics. 18:811. (2017).